фармакология
Emerging Technology Platforms for Stem Cells
Uma Lakshmipathy
This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key...
Genomics in Drug Discovery and Development
Dimitri Semizarov
Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative...
Immunotoxicology Strategies for Pharmaceutical Safety Assessment
Danuta Herzyk J.
An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to...
Development and Approval of Combination Products
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A step-by-step, integrated approach for successful, FDA-approved combination drug products Using a proven integrated approach to combination drug development, this book guides you step by step through all the preclinical, clinical, and...
Essential Statistics for the Pharmaceutical Sciences
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… this text takes a novel approach… The style… is not as dry as other statistics texts, and so should not be intimidating even to a relative newcomer to the subject… The layout is easy to navigate, there are chapter aims, summaries and “key...
NMR Spectroscopy in Drug Development and Analysis
Iwona Wawer
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and...
Evaluating Pharmaceuticals for Health Policy and Reimbursement
Nick Freemantle
“The challenge in all settings is to make the difficult decisions in a way that is defensible, justifiable, ethical, and equitable” So write Nick Freemantle and Suzanne Hill in their introduction to this important discussion on decision making...
Principles of Psychopharmacology for Mental Health Professionals
Charles Nemeroff B.
Principles of Psychopharmacology for Mental Health Professionals addresses the current «split» model of mental health care, in which physicians provide pharmaco-therapy while non-prescribing practitioners oversee other services such as...
An Introduction to Statistics in Early Phase Trials
David Machin
All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these...
Stephens' Detection of New Adverse Drug Reactions
John Talbot
A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate...
Computer Applications in Pharmaceutical Research and Development
Sean Ekins
A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work...
Statistical Thinking for Non-Statisticians in Drug Regulation
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Written by a well-known lecturer and consultant to the pharmaceutical industry, this book focuses on the pharmaceutical non-statistician working within a very strict regulatory environment. Statistical Thinking for Clinical Trials in Drug...
Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio
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ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It...
Privileged Structures in Drug Discovery
Larry Yet
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery...
Drug Selectivity
Raimund Mannhold
The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development...
Biomolecular Simulations in Structure-Based Drug Discovery
Raimund Mannhold
A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals...
Data Monitoring Committees in Clinical Trials. A Practical Perspective
Thomas Fleming R.
The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim...
Biomolecular Simulations in Structure-Based Drug Discovery
Raimund Mannhold
A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals...
Drug Selectivity. An Evolving Concept in Medicinal Chemistry
Raimund Mannhold
The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development...
Drug Utilization Research
Bj?rn Wettermark
Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines...
Transporters as Drug Targets
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As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents...
Thermodynamics and Kinetics of Drug Binding
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This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics...
Predictive Toxicology
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Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety...
Essential Practical Prescribing
Victoria Taylor
Essential Practical Prescribing is an important new textbook with a clinical, ward-based focus. It is specifically designed to help new foundation doctors working on the hospital wards and in the community, as well as medical students preparing...
Drug Discovery Toxicology
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As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides...
ICH Quality Guidelines
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Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and...
Protein Therapeutics, 2 Volume Set
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In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal...
Drug Metabolism Prediction
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The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research...
Data Mining in Drug Discovery
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Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection...
Molecular Pharmacology
John Dickenson
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide...
Fragment-based Drug Discovery
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From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this...
Animal Models for Human Cancer
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Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results....
Handbook of Chemical and Biological Plant Analytical Methods
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Plants and plant-derived compounds and drugs are becoming more and more popular with increasing numbers of scientists researching plant analysis. The quality control of herbal drugs is also becoming essential to avoid severe health problems, and...
Natural Products in Medicinal Chemistry
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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the...
Scaffold Hopping in Medicinal Chemistry
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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing...
Prescribing Scenarios at a Glance
Emma Baker
Prescribing Scenarios at a Glance is an innovative resource which allows medical students and junior doctors to practise prescribing skills safely for themselves. Supporting those who wish to develop their prescribing knowledge and clinical...
Novel Antimicrobial Agents and Strategies
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By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a...
In vivo Models for Drug Discovery
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This one-stop reference is the first to present the complete picture – covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases....
Natural Products Targeting Clinically Relevant Enzymes
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The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by...
Targeted Biomarker Quantitation by LC-MS
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The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in...
Successful Drug Discovery, Volume 2
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Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted...
Antibiotics Manual
David L. Schlossberg
A comprehensive compendium of all commonly used antibiotics, including indications, side effects, dosage information, and drug/food interactions Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a unique,...
Nonclinical Safety Assessment
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Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental...
Attrition in the Pharmaceutical Industry
Dennis A. Smith
With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and...
Quantitative Methods for Health Research
Nigel Bruce
A practical introduction to epidemiology, biostatistics, and research methodology for the whole health care community This comprehensive text, which has been extensively revised with new material and additional topics, utilizes a practical slant...
Analogue-based Drug Discovery III
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Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new...
Antibody-Drug Conjugates
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Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics,...
Structure-based Design of Drugs and Other Bioactive Molecules
Arun K. Ghosh
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic...
Method Validation in Pharmaceutical Analysis
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This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the...
Production of Plasma Proteins for Therapeutic Use
Joseph Bertolini
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a...
