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  • фармакология

    Lodola Alberto. Pharmaceutical Toxicology in Practice. A Guide to Non-clinical Development

    Pharmaceutical Toxicology in Practice. A Guide to Non-clinical Development

    Lodola Alberto

    This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the...
    Urban Laszlo. Predictive ADMET. Integrated Approaches in Drug Discovery and Development

    Predictive ADMET. Integrated Approaches in Drug Discovery and Development

    Urban Laszlo

    This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can...
    Hansen Neal. Pharmaceutical Lifecycle Management. Making the Most of Each and Every Brand

    Pharmaceutical Lifecycle Management. Making the Most of Each and Every Brand

    Hansen Neal

    A comprehensive guide to optimizing the lifecycle management of pharmaceutical brands The mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand...
    Castanho Miguel. Peptide Drug Discovery and Development. Translational Research in Academia and Industry

    Peptide Drug Discovery and Development. Translational Research in Academia and Industry

    Castanho Miguel

    Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the «bench to bedside» translational approach to drug development. Clearly structured into three major parts, the book stakes...
    Litwin Virginia. Flow Cytometry in Drug Discovery and Development

    Flow Cytometry in Drug Discovery and Development

    Litwin Virginia

    This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow...
    Wood Terry. Management of Chemical and Biological Samples for Screening Applications

    Management of Chemical and Biological Samples for Screening Applications

    Wood Terry

    Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of...
    Jiskoot Wim. Analysis of Aggregates and Particles in Protein Pharmaceuticals

    Analysis of Aggregates and Particles in Protein Pharmaceuticals

    Jiskoot Wim

    This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles,...
    Adler Lawrence. Clinical Trials in Psychopharmacology. A Better Brain

    Clinical Trials in Psychopharmacology. A Better Brain

    Adler Lawrence

    Although clinical trials were virtually unheard of in psychiatry for many years, they are now the gold standard for judging whether drugs are safe and useful. But should they be? What is the true status of clinical trials? Even when they...
    Hu Ming. Oral Bioavailability. Basic Principles, Advanced Concepts, and Applications

    Oral Bioavailability. Basic Principles, Advanced Concepts, and Applications

    Hu Ming

    Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles,...
    Stuart Walker. Benefit-Risk Appraisal of Medicines

    Benefit-Risk Appraisal of Medicines

    Stuart Walker

    Benefit-risk assessment is at the centre of the approval process for every new medicine. The ability to assess the risks of a new medicine accurately and to balance these against the benefits the medicine could bring is critical for every...
    Группа авторов. Predictive Approaches in Drug Discovery and Development

    Predictive Approaches in Drug Discovery and Development

    Группа авторов

    Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and...
    J?rg K?nig. Pharmacogenomics of Human Drug Transporters

    Pharmacogenomics of Human Drug Transporters

    J?rg K?nig

    Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and...
    Andrew Batchelder. Rapid Clinical Pharmacology

    Rapid Clinical Pharmacology

    Andrew Batchelder

    This pocket reference guide is a must for all medical students and junior doctors preparing for exams in pharmacology or needing a rapid reminder during a clinical attachment. In light of the growing pressures on those who prescribe drugs to...
    Jan A. Rosier. Global New Drug Development

    Global New Drug Development

    Jan A. Rosier

    The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service...
    Michael Wiese. Drug-Membrane Interactions

    Drug-Membrane Interactions

    Michael Wiese

    Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane...
    Группа авторов. Evaluation of Drug Candidates for Preclinical Development

    Evaluation of Drug Candidates for Preclinical Development

    Группа авторов

    Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the «right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D...
    Группа авторов. Drug Design of Zinc-Enzyme Inhibitors

    Drug Design of Zinc-Enzyme Inhibitors

    Группа авторов

    Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins...
    Группа авторов. Drug Bioavailability

    Drug Bioavailability

    Группа авторов

    The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's...
    Bi-Botti Youan C.. Chronopharmaceutics. Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

    Chronopharmaceutics. Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

    Bi-Botti Youan C.

    Chronopharmaceutics Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in...
    Группа авторов. Virtual Screening

    Virtual Screening

    Группа авторов

    Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are...
    Minghan  Wang. Metabolic Syndrome. Underlying Mechanisms and Drug Therapies

    Metabolic Syndrome. Underlying Mechanisms and Drug Therapies

    Minghan Wang

    This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated...
    Группа авторов. ABC Transporters and Multidrug Resistance

    ABC Transporters and Multidrug Resistance

    Группа авторов

    A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance...
    Группа авторов. Antibiotics

    Antibiotics

    Группа авторов

    Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to...
    Группа авторов. Prodrugs and Targeted Delivery

    Prodrugs and Targeted Delivery

    Группа авторов

    This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and...
    Группа авторов. Hugo and Russell's Pharmaceutical Microbiology

    Hugo and Russell's Pharmaceutical Microbiology

    Группа авторов

    Pharmaceutical microbiology has a bearing on all aspects of pharmacy, from the manufacture and quality control of pharmaceutical products through to an understanding of the mode of action of antibiotics. Fully revised and restructured, drawing...
    Группа авторов. Medicinal Chemistry of Nucleic Acids

    Medicinal Chemistry of Nucleic Acids

    Группа авторов

    Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications,...
    Группа авторов. Protein and Peptide Mass Spectrometry in Drug Discovery

    Protein and Peptide Mass Spectrometry in Drug Discovery

    Группа авторов

    The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to...
    Andrew E. Mulberg. Pediatric Drug Development

    Pediatric Drug Development

    Andrew E. Mulberg

    Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications,...
    Kun Cheng. Advanced Drug Delivery

    Advanced Drug Delivery

    Kun Cheng

    Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug...
    Группа авторов. The Textbook of Pharmaceutical Medicine

    The Textbook of Pharmaceutical Medicine

    Группа авторов

    The Textbook of Pharmaceutical Medicine is the standard reference for everyone working and learning in pharmaceutical medicine. It is a comprehensive resource covering the processes and practices by which medicines are developed, tested and...
    Michael F. Murphy. Critical Pathways to Success in CNS Drug Development

    Critical Pathways to Success in CNS Drug Development

    Michael F. Murphy

    Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve...
    Ryan F. Donnelly. Microneedle-mediated Transdermal and Intradermal Drug Delivery

    Microneedle-mediated Transdermal and Intradermal Drug Delivery

    Ryan F. Donnelly

    Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery....
    Группа авторов. Aspartic Acid Proteases as Therapeutic Targets

    Aspartic Acid Proteases as Therapeutic Targets

    Группа авторов

    In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological...
    Группа авторов. Principles and Practice of Pharmaceutical Medicine

    Principles and Practice of Pharmaceutical Medicine

    Группа авторов

    The new edition of Principles and Practice of Pharmaceutical Medicine is a comprehensive reference guide to all aspects of pharmaceutical medicine. New content includes chapters and coverage on regulatory updates, increasing international...
    Sukhdev  Chatu. The Hands-on Guide to Clinical Pharmacology

    The Hands-on Guide to Clinical Pharmacology

    Sukhdev Chatu

    Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical...
    Группа авторов. Chemokine Receptors as Drug Targets

    Chemokine Receptors as Drug Targets

    Группа авторов

    Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling...
    Группа авторов. Pharmacokinetics and Metabolism in Drug Design

    Pharmacokinetics and Metabolism in Drug Design

    Группа авторов

    In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained,...
    Группа авторов. Protein-Protein Interactions in Drug Discovery

    Protein-Protein Interactions in Drug Discovery

    Группа авторов

    Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their...
    Группа авторов. Bioisosteres in Medicinal Chemistry

    Bioisosteres in Medicinal Chemistry

    Группа авторов

    Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a...
    Группа авторов. Phosphodiesterases and Their Inhibitors

    Phosphodiesterases and Their Inhibitors

    Группа авторов

    Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug...
    Группа авторов. Antiviral Drug Strategies

    Antiviral Drug Strategies

    Группа авторов

    By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins...
    Группа авторов. Protein-Ligand Interactions

    Protein-Ligand Interactions

    Группа авторов

    Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand...
    Deepak Dalvie. Reactive Drug Metabolites

    Reactive Drug Metabolites

    Deepak Dalvie

    Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our...
    Группа авторов. Fusion Protein Technologies for Biopharmaceuticals

    Fusion Protein Technologies for Biopharmaceuticals

    Группа авторов

    The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as...
    Klara Valko. Physicochemical and Biomimetic Properties in Drug Discovery, Enhanced Edition

    Physicochemical and Biomimetic Properties in Drug Discovery, Enhanced Edition

    Klara Valko

    Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships...
    Группа авторов. Neuroprotective Natural Products

    Neuroprotective Natural Products

    Группа авторов

    Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and...
    Группа авторов. Biophysical Methods for Biotherapeutics

    Biophysical Methods for Biotherapeutics

    Группа авторов

    With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and...
    Y. Robert Li. Cardiovascular Diseases

    Cardiovascular Diseases

    Y. Robert Li

    Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular...
    Brian S. Fulton. Drug Discovery for the Treatment of Addiction

    Drug Discovery for the Treatment of Addiction

    Brian S. Fulton

    With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in...
    Kristin Ciriello Pothier. Personalizing Precision Medicine

    Personalizing Precision Medicine

    Kristin Ciriello Pothier

    The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics,...
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