фармакология
Novel Therapeutic Targets for Antiarrhythmic Drugs
George Billman Edward
Profiles potential treatment approaches for cardiac arrhythmias Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases...
Detection and Quantification of Antibodies to Biopharmaceuticals. Practical and Applied Considerations
Michael Tovey G.
The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When...
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations. Principles, Methods, and Applications in the Pharmaceutical Industry
Sheila Peters Annie
The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade,...
Pharmazeutische Mikrobiologie. Qualit?tssicherung, Monitoring, Betriebshygiene
Michael Rieth
Die pharmazeutische Mikrobiologie hat sich in den letzten Jahrzehnten von einer hochspezialisierten Wissenschaft zu einer Querschnittdisziplin entwickelt, die fur Pharmazeuten, Mikrobiologen, aber auch Mediziner und...
Chronopharmaceutics. Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases
Bi-Botti Youan C.
Chronopharmaceutics Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in...
Early Drug Development. Strategies and Routes to First-in-Human Trials
Mitchell Cayen N.
The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in...
Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications
Kiyohiko Sugano
A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development...
Statistical Thinking for Non-Statisticians in Drug Regulation
Richard Kay
Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides...
Applications of Microdialysis in Pharmaceutical Science
Tung-Hu Tsai
Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular...
Biopharmaceutical Production Technology, 2 Volume Set
Ganapathy Subramanian
Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and...
Development of Therapeutic Agents Handbook
Shayne Cox Gad
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic...
The Hands-on Guide to Clinical Pharmacology
Sukhdev Chatu
Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical...
Antibiotics and Antibiotic Resistance
Ola Skold
This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future...
Polypharmacology in Drug Discovery
Jens-Uwe Peters
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is...
Prescribing at a Glance
Sarah Ross
The principles of drug therapies are fundamental to medical practitioners in all branches; but are often difficult to get to grips with. Prescribing at a Glance addresses the most common uses of prescription drugs, and follows progress from dose...
An Introduction to Pharmacovigilance
Patrick Waller
Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems. This introductory guide is designed to aid the rapid understanding of the...
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery
West Anthony R.
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest...
Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders
Gomtsyan Arthur
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including...
Topical and Transdermal Drug Delivery. Principles and Practice
Benson Heather A.E.
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field...
The Agile Approach to Adaptive Research. Optimizing Efficiency in Clinical Development
Ekins Sean
Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a...
Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad
Lu Chuang
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and...
Analogue-based Drug Discovery II
Ganellin C. Robin
Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog...
Dendrimer-Based Drug Delivery Systems. From Theory to Practice
Tomalia Donald A.
The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have...
Pediatric Non-Clinical Drug Testing. Principles, Requirements, and Practice
Lewis Elise M.
This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences...
Pharmacogenetics and Individualized Therapy
Anke-Hilse Maitland-van der Zee
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following...
Pharmacogenomics in Clinical Therapeutics
Dasgupta Amitava
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics...
Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs
Barratt Michael J.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical,...
Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools
Ekins Sean
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary...
Stephens' Detection and Evaluation of Adverse Drug Reactions. Principles and Practice
Talbot John
The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of...
Label-Free Technologies For Drug Discovery
Mayr Lorenz M.
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies...
Targets and Emerging Therapies for Schizophrenia
Wood Michael W.
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of...
Development of Vaccines. From Discovery to Clinical Testing
Srivastava Indresh K.
Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the...
Applications of Ion Chromatography in the Analysis of Pharmaceutical and Biological Products
Bhattacharyya Lokesh
This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument...
RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development
Rossi John J.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team....
Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena
Findlay John W.
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in...
Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies
Young Richard
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a...
Case Studies in Modern Drug Discovery and Development
Huang Xianhai
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and...
Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications
Mecozzi Sandro
Designed for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical...
Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery
Ekins Sean
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological,...
Systems Biology in Drug Discovery and Development
Young Daniel L.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the...
ADMET for Medicinal Chemists. A Practical Guide
Tsaioun Katya
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing...
Clinical Pharmacology and Therapeutics
Walters Matthew R.
Clinical Pharmacology and Therapeutics Lecture Notes provides a clear and accessible overview of all the key prescribing topics needed for medical finals and beyond. Detailed coverage and discussion of pharmacology in a clinical context,...
Therapeutic Targets. Modulation, Inhibition, and Activation
Botana Luis M.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of...
Drug-Drug Interactions for Therapeutic Biologics
Zhou Honghui
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the...
Collaborative Innovation in Drug Discovery. Strategies for Public and Private Partnerships
Murad Ferid
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing...
Carbohydrate Recognition. Biological Problems, Methods, and Applications
Wang Binghe
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems...
A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim
Davis Kate
The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly...
Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action
Li Chun
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the...
Lead Generation Approaches in Drug Discovery
Rankovic Zoran
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding...
Pharmacotherapy of Child and Adolescent Psychiatric Disorders
Gershon Samuel
This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the...
