фармакология
Stephens' Detection and Evaluation of Adverse Drug Reactions. Principles and Practice
Talbot John
The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of...
Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools
Ekins Sean
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary...
Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs
Barratt Michael J.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical,...
Pharmacogenomics in Clinical Therapeutics
Dasgupta Amitava
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics...
Pharmacogenetics and Individualized Therapy
Anke-Hilse Maitland-van der Zee
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following...
Pediatric Non-Clinical Drug Testing. Principles, Requirements, and Practice
Lewis Elise M.
This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences...
Dendrimer-Based Drug Delivery Systems. From Theory to Practice
Tomalia Donald A.
The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have...
Analogue-based Drug Discovery II
Ganellin C. Robin
Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog...
Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad
Lu Chuang
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and...
The Agile Approach to Adaptive Research. Optimizing Efficiency in Clinical Development
Ekins Sean
Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a...
Topical and Transdermal Drug Delivery. Principles and Practice
Benson Heather A.E.
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field...
Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders
Gomtsyan Arthur
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including...
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery
West Anthony R.
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest...
An Introduction to Pharmacovigilance
Patrick Waller
Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems. This introductory guide is designed to aid the rapid understanding of the...
Prescribing at a Glance
Sarah Ross
The principles of drug therapies are fundamental to medical practitioners in all branches; but are often difficult to get to grips with. Prescribing at a Glance addresses the most common uses of prescription drugs, and follows progress from dose...
Polypharmacology in Drug Discovery
Jens-Uwe Peters
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is...
Antibiotics and Antibiotic Resistance
Ola Skold
This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future...
The Hands-on Guide to Clinical Pharmacology
Sukhdev Chatu
Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical...
Development of Therapeutic Agents Handbook
Shayne Cox Gad
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic...
Biopharmaceutical Production Technology, 2 Volume Set
Ganapathy Subramanian
Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and...
Applications of Microdialysis in Pharmaceutical Science
Tung-Hu Tsai
Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular...
Statistical Thinking for Non-Statisticians in Drug Regulation
Richard Kay
Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides...
Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications
Kiyohiko Sugano
A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development...
Early Drug Development. Strategies and Routes to First-in-Human Trials
Mitchell Cayen N.
The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in...
Chronopharmaceutics. Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases
Bi-Botti Youan C.
Chronopharmaceutics Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in...
Pharmazeutische Mikrobiologie. Qualit?tssicherung, Monitoring, Betriebshygiene
Michael Rieth
Die pharmazeutische Mikrobiologie hat sich in den letzten Jahrzehnten von einer hochspezialisierten Wissenschaft zu einer Querschnittdisziplin entwickelt, die fur Pharmazeuten, Mikrobiologen, aber auch Mediziner und...
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations. Principles, Methods, and Applications in the Pharmaceutical Industry
Sheila Peters Annie
The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade,...
Detection and Quantification of Antibodies to Biopharmaceuticals. Practical and Applied Considerations
Michael Tovey G.
The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When...
Novel Therapeutic Targets for Antiarrhythmic Drugs
George Billman Edward
Profiles potential treatment approaches for cardiac arrhythmias Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases...
Metabolic Syndrome. Underlying Mechanisms and Drug Therapies
Minghan Wang
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated...
Genotoxic Impurities. Strategies for Identification and Control
Andrew Teasdale
This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both...
Compatibility of Pharmaceutical Solutions and Contact Materials. Safety Assessments of Extractables and Leachables for Pharmaceutical Products
Dennis Jenke
Compatibility of Pharmaceutical Products and Contact Materials Dennis Jenke Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers Compatibility of Pharmaceutical...
Drugs of Abuse. Pharmacology and Molecular Mechanisms
Sherrel Howard
Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding...
Absorption and Drug Development. Solubility, Permeability, and Charge State
Alex Avdeef
Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's...
Pharmaceutical Anti-Counterfeiting. Combating the Real Danger from Fake Drugs
Mark Davison
This book overviews and integrates the business and technical issues that pharmaceutical companies need to know in order to combat the major global problem of counterfeit medicines. In addition to discussion of the problems, the author Davison...
Devalued and Distrusted. Can the Pharmaceutical Industry Restore its Broken Image?
John LaMattina L.
An expert's view on solving the challenges confronting today's pharmaceutical industry Author John LaMattina, a thirty-year veteran of the pharmaceutical industry and former president of Pfizer's Global R&D Division, is internationally...
BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease
Varghese John
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the...
Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates
Paul Selzer M.
Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists....
Cost-Contained Regulatory Compliance. For the Pharmaceutical, Biologics, and Medical Device Industries
Sandy Weinberg
This book guides the reader through FDA regulation guidelines and outlines a comprehensive strategy for cost reduction in regulatory affairs and compliance. This book explains six strategies to cost-effectively comply with FDA regulations while...
Supply Chain Management in the Drug Industry. Delivering Patient Value for Pharmaceuticals and Biologics
Hedley Rees
This book bridges the gap between practitioners of supply-chain management and pharmaceutical industry experts. It aims to help both these groups understand the different worlds they live in and how to jointly contribute to meaningful...
The Use and Misuse of Psychiatric Drugs. An Evidence-Based Critique
Joel Paris
Dr. Paris has written an honest, balanced presentation of the ways in which psychiatric drugs are evaluated and prescribed. He highlights the complexity of the task, the limits of what is known and the mixed picture that research often produces....
Clinical Trials Audit Preparation. A Guide for Good Clinical Practice (GCP) Inspections
Vera Mihajlovic-Madzarevic
A must-have guide for any professional in the drug manufacturing industry The Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA...
Drug Metabolism Handbook. Concepts and Applications
Ala Nassar F.
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by...
Plasmid Biopharmaceuticals. Basics, Applications, and Manufacturing
Duarte Miguel F. Prazeres
The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes...
Pharmacovigilance Medical Writing. A Good Practice Guide
Justina Orleans-Lindsay
Pharmacovigilance Medical Writing covers the preparation of pharmacovigilance documents for all stages of the drug development process (i.e. from clinical development through to applications for marketing authorisations to the post-marketing...
Antiviral Drugs. From Basic Discovery Through Clinical Trials
Wieslaw Kazmierski M.
This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical...
Drug Truths. Dispelling the Myths About Pharma R & D
John LaMattina L.
This book answers the questions about the process and costs of pharmaceutical R & D in a compelling narrative focused on the discovery and development of important new medicines. It gives an insider's account of the pharmaceutical industry drug...
Практические вопросы клинической коагулологии
Вячеслав Дмитриев
Издание содержит научно-практические сведения о системе свертывания, необходимые для практической работы врача, сталкивающегося с вопросами профилактики тромбозов и кровотечений у пациентов различного профиля. Книга включает информацию,...
Трансдермальное введение лекарственных веществ и физические факторы
В. С. Улащик
Книга посвящена влиянию физических факторов различной природы на трансдермальный (чрескожный) транспорт лекарственных веществ. На основе представлений о структуре и барьерных свойствах кожи дается анализ использования физических агентов для...
Лекарства. Недорогие и эффективные препараты для домашней аптечки
Ренад Аляутдин
Справочник содержит описание механизмов действия и свойств наиболее часто применяемых современных лекарственных средств, выпускаемых отечественными и зарубежными фармацевтическими компаниями. Для удобства пользования материал разбит на...
