фармакология
Advanced Drug Delivery
Kun Cheng
Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug...
Pediatric Drug Development
Andrew E. Mulberg
Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications,...
Protein and Peptide Mass Spectrometry in Drug Discovery
Группа авторов
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to...
Medicinal Chemistry of Nucleic Acids
Группа авторов
Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications,...
Hugo and Russell's Pharmaceutical Microbiology
Группа авторов
Pharmaceutical microbiology has a bearing on all aspects of pharmacy, from the manufacture and quality control of pharmaceutical products through to an understanding of the mode of action of antibiotics. Fully revised and restructured, drawing...
Prodrugs and Targeted Delivery
Группа авторов
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and...
Antibiotics
Группа авторов
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to...
ABC Transporters and Multidrug Resistance
Группа авторов
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance...
Metabolic Syndrome. Underlying Mechanisms and Drug Therapies
Minghan Wang
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated...
Virtual Screening
Группа авторов
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are...
Chronopharmaceutics. Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases
Bi-Botti Youan C.
Chronopharmaceutics Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in...
Drug Bioavailability
Группа авторов
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's...
Drug Design of Zinc-Enzyme Inhibitors
Группа авторов
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins...
Evaluation of Drug Candidates for Preclinical Development
Группа авторов
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the «right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D...
Drug-Membrane Interactions
Michael Wiese
Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane...
Global New Drug Development
Jan A. Rosier
The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service...
Rapid Clinical Pharmacology
Andrew Batchelder
This pocket reference guide is a must for all medical students and junior doctors preparing for exams in pharmacology or needing a rapid reminder during a clinical attachment. In light of the growing pressures on those who prescribe drugs to...
Pharmacogenomics of Human Drug Transporters
J?rg K?nig
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and...
Predictive Approaches in Drug Discovery and Development
Группа авторов
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and...
Benefit-Risk Appraisal of Medicines
Stuart Walker
Benefit-risk assessment is at the centre of the approval process for every new medicine. The ability to assess the risks of a new medicine accurately and to balance these against the benefits the medicine could bring is critical for every...
Oral Bioavailability. Basic Principles, Advanced Concepts, and Applications
Hu Ming
Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles,...
Clinical Trials in Psychopharmacology. A Better Brain
Adler Lawrence
Although clinical trials were virtually unheard of in psychiatry for many years, they are now the gold standard for judging whether drugs are safe and useful. But should they be? What is the true status of clinical trials? Even when they...
Analysis of Aggregates and Particles in Protein Pharmaceuticals
Jiskoot Wim
This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles,...
Management of Chemical and Biological Samples for Screening Applications
Wood Terry
Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of...
Flow Cytometry in Drug Discovery and Development
Litwin Virginia
This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow...
Peptide Drug Discovery and Development. Translational Research in Academia and Industry
Castanho Miguel
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the «bench to bedside» translational approach to drug development. Clearly structured into three major parts, the book stakes...
Pharmaceutical Lifecycle Management. Making the Most of Each and Every Brand
Hansen Neal
A comprehensive guide to optimizing the lifecycle management of pharmaceutical brands The mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand...
Predictive ADMET. Integrated Approaches in Drug Discovery and Development
Urban Laszlo
This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can...
Pharmaceutical Toxicology in Practice. A Guide to Non-clinical Development
Lodola Alberto
This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the...
Pharmacotherapy of Child and Adolescent Psychiatric Disorders
Gershon Samuel
This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the...
Lead Generation Approaches in Drug Discovery
Rankovic Zoran
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding...
Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action
Li Chun
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the...
A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim
Davis Kate
The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly...
Carbohydrate Recognition. Biological Problems, Methods, and Applications
Wang Binghe
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems...
Collaborative Innovation in Drug Discovery. Strategies for Public and Private Partnerships
Murad Ferid
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing...
Drug-Drug Interactions for Therapeutic Biologics
Zhou Honghui
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the...
Therapeutic Targets. Modulation, Inhibition, and Activation
Botana Luis M.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of...
Clinical Pharmacology and Therapeutics
Walters Matthew R.
Clinical Pharmacology and Therapeutics Lecture Notes provides a clear and accessible overview of all the key prescribing topics needed for medical finals and beyond. Detailed coverage and discussion of pharmacology in a clinical context,...
ADMET for Medicinal Chemists. A Practical Guide
Tsaioun Katya
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing...
Systems Biology in Drug Discovery and Development
Young Daniel L.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the...
Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery
Ekins Sean
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological,...
Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications
Mecozzi Sandro
Designed for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical...
Case Studies in Modern Drug Discovery and Development
Huang Xianhai
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and...
Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies
Young Richard
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a...
Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena
Findlay John W.
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in...
RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development
Rossi John J.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team....
Applications of Ion Chromatography in the Analysis of Pharmaceutical and Biological Products
Bhattacharyya Lokesh
This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument...
Development of Vaccines. From Discovery to Clinical Testing
Srivastava Indresh K.
Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the...
Targets and Emerging Therapies for Schizophrenia
Wood Michael W.
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of...
Label-Free Technologies For Drug Discovery
Mayr Lorenz M.
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies...
