Quantitative studies on structure-activity and structure-property relationships are powerful tools in directed drug research. In recent years, various strategies have been developed to characterize and classify structural patterns by means of...
Adhesion is among the oldest technologies known to mankind, but the technology of adhesives began to boom with the developments in chemistry in the early 1900s. The last few years have seen tremendous progress in the performance of adhesives,...
Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it...
This book builds up on the success of the first edition of Paints, Coatings, and Solvents. The first edition has been completely revised, the second edition thus is an up-to-date overview of the industrial aspects of paints, coatings, and...
A comprehensive overview of the demands on pharmaceutical products and manufacturing processes. It describes in detail the requirements for pharmaceutical production plants, production processes, equipment and machinery, as well as the...
This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an...
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors...
Until now colloid science books have either been theoretical, or focused on specific types of dispersion, or on specific applications. This then is the first book to provide an integrated introduction to the nature, formation and occurrence,...
Micro process engineering is approaching both academia and industry. With the provision of micro devices, systems and whole plants by commercial suppliers, one main barrier for using these units has been eliminated. This book focuses on...
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field,...
Micro process engineering is approaching both academia and industry. With the provision of micro devices and systems by commercial suppliers, one main barrier for using these units has been eliminated. More and more they become familiar, thereby...
A comprehensive and up-to-date overview of the major mineral and organic fillers for plastics, their production, structure and properties, as well as their applications in terms of primary and secondary functions. Edited and co-authored by...
This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia...
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery...
Photochemistry of Organic Compounds: From Concepts to Practice provides a hands-on guide demonstrating the underlying principles of photochemistry and, by reference to a range of organic reaction types, its effective use in the synthesis of new...
The first reports on the application of microwaves in organic synthesis date back to 1986, but it was not until the recent introduction of specifically designed and constructed equipment, which countered the safety and reproducibility concerns,...
The development of university organic chemistry curricula and the trend towards modularisation of chemistry courses has driven the need for smaller, highly focussed and accessible organic chemistry textbooks, which complement the very detailed...
The first systematic summary of biophysical mass spectrometry techniques Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's...
Whether a company operates global facilities or just imports/exports goods to the United States, personnel and advisors must understand regulatory requirements. Most companies that ship or receive goods internationally have developed MCS that...
A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses....
Volatile organic solvents are the normal media used in both research scale and industrial scale synthesis of organic chemicals. Their environmental impact is significant, however, and so the development of alternative reaction media has become...
Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring...
This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to...
First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be...
Carbohydrates offer a ready source of enantiomerically pure starting materials. They have been used for the imaginative synthesis of a wide range of compounds, and have been found to be effective chiral auxiliaries which enable the introduction...
Concentration on renewable resources, sustainability and replacement of oil based products are driving forces to reassess the potential of natural resources including natural colorants. The growing consumer interest in purchasing “green”...
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules – fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical...
Most modern surfactants are readily biodegradable and exhibit low toxicity in the aquatic environment, the two criteria for green surfactants. However the majority are synthesised from petroleum, so over the past decade the detergent industry...
Recoverable and Recyclable Catalysts There is continued pressure on chemical and pharmaceutical industries to reduce chemical waste and improve the selectivity and efficiency of synthetic processes. The need to implement green chemistry...
The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives...
Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to environmental factors. The isolation and characterization of plant products, the identification of...
This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student… the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read. –Journal of...
State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular...
This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and...
An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an...
An overview of nanotechnology and its potential The field of nanotechnology is undergoing rapid developments on many fronts. This reference provides a comprehensive review of various nanotechnologies with a view to their biomedical applications....
A practical guide for ensuring a defect-free coating and drying process For professionals in the coating and drying industry, the world is a demanding place. New, technically complex products such as fuel cell membranes, thin film batteries,...
Owing to the limited resources of fossil fuels, hydrogen is proposed as an alternative and environment-friendly energy carrier. However, its potential is limited by storage problems, especially for mobile applications. Current technologies, as...
This systematic introduction to the topic includes theoretical concepts to help readers understand and predict surface forces, while also integrating experimental techniques and practical applications with up-to-date examples plus motivating...
An excellent resource for all graduate students and researchers using electrochemical techniques. After introducing the reader to the fundamentals, the book focuses on the latest developments in the techniques and applications in this field....
The only comprehensive handbook on this important and rapidly developing topic combines fundamental information with a brief overview of recent advances in solid state electrochemistry, primarily targeting specialists working in this scientific...
Filling a gap in the current literature, this comprehensive reference presents all important catalyst classes, including metal oxides, polyoxometalates, and zeolites. Readers will find here everything they need to know – from structure design to...
Solid catalysts play a fundamental role in all areas between basic research and industrial applications. This book offers a large amount of information about the preparation of solid catalysts. All types of solid catalysts and all important...
Many different chemical processes take place inside solids or at solid surfaces and interfaces. However, their quantitative description sometimes seems difficult to understand. This book by Professor Schmalzried, author of the eminently...
This first book to focus on catalytic processes from the viewpoint of green chemistry presents every important aspect: ? Numerous catalytic reductions and oxidations methods ? Solid-acid and solid-base catalysis ? C-C bond formation reactions ?...
An excellent overview of the manifold aspects of modern crystal engineering. From design and preparation to spectroscopy and applications, this handbook both covers and evaluates all aspects of crystal engineering. Clearly structured, it...
Focusing on both academic questions and applications of self-assembly of this extremely important class of compounds, this book discusses not only the self-organization of inorganic and magnetic nanocrystals, but also their collective optical...
The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. • This is the only series of volumes available that presents the...
Ab initio quantum chemistry has emerged as an important tool in chemical research and is appliced to a wide variety of problems in chemistry and molecular physics. Recent developments of computational methods have enabled previously intractable...
FROM REVIEWS OF THE SERIES «Reviews in Computational Chemistry remains the most valuable reference to methods and techniques in computational chemistry.» -JOURNAL OF MOLECULAR GRAPHICS AND MODELLING «One cannot generally do better than to try to...