The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as...
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and...
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and...
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical...
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies...
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research,...
Nature provides us with an abundance of chemical potential. Presenting an overview of the use of bioresources in the 21st century, Introduction to Chemicals from Biomass covers resources, chemical composition of biomass, key factors affecting...
This extensively updated and revised version builds on the success of the first edition featuring new discoveries in powder technology, spraying techniques, new coatings applications and testing techniques for coatings – Many new spray...
At a time when environmental concerns are increasing, it's important that chemical processes are as environmentally friendly as possible. This book outlines various methods for producing inorganic and organic solvents without the use of...
A guide to achieving business successes through statistical methods Statistical methods are a key ingredient in providing data-based guidance to research and development as well as to manufacturing. Understanding the concepts and specific steps...
Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds...
This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Includes case studies of the discovery of...
A Complete overview of theory, selection, design, operation, and maintenance This text offers a thorough overview of the operating characteristics, efficiencies, design features, troubleshooting, and maintenance of dynamic and positive...
Radicals and radical ions are important intermediates with wide use in organic synthesis. The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic...
Familiarizes the student or an engineer new to process safety with the concept of process safety management Serves as a comprehensive reference for Process Safety topics for student chemical engineers and newly graduate engineers Acts as a...
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and...
While existing books related to DOE are focused either on process or mixture factors or analyze specific tools from DOE science, this text is structured both horizontally and vertically, covering the three most common objectives of any...
This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special...
Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have...
Mastering management skills is hard to achieve by newcomers starting their careers in the chemical industry. The message coming from there is that good chemists swiftly have to become good managers if they are to survive and progress in today's...
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program....
Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing...
Get a good start in flavor and fragrance chemistry! This book presents a survey of those natural and synthetic fragrance and flavor materials which are commercially available, produced and used on a relatively large scale and which are important...
This first comprehensive handbook on the subject describes the manufacturing processes of various types of papers, recovered paper treatment, as well as the quality and economical aspects. More than 20 authors contribute a variety of viewpoints,...
A guide for younger R&D chemists as to how they can quickly evolve skills built around three factors – people, knowledge and time. It covers the management of scientific personnel, management within a variety of R & D organizational structures,...
Bei der Herstellung von Produkten und Verbrauchsgutern in verfahrenstechnischen Produktionsanlagen ist die Kristallisation ein wesentlicher Verfahrensschritt, um bei Stofftrennprozessen eine hohe Reinheit zu erzielen. Diese...
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general...
Get a good start in flavor and fragrance chemistry! This book presents a survey of those natural and synthetic fragrance and flavor materials which are isolated and produced commercially on a relatively large scale because of their organoleptic...
The new definitive reference in the field. Between them, the renowned team of editors and authors have amassed unparalleled experience at such institutes as BAM, PTB, Pittsburgh National Institute for Occupational Health and Safety, BASF AG, and...
Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in the pharmaceutical industry. New challenges in synthesis result in new analytical methods. At...
When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the...
Plastics have developed into the most important class of packaging materials. Their relative impermeability for substances from the surroundings has great influence on the shelf life and the quality of the packed goods. At the same time the...
Production-integrated environmental protection is synonymous with – reducing the amount of potential pollutants at source – reducing the consumption of resources and energy – recycling and utilization of residues and used products, and therefore...
Characterization of fine particles is a difficult task! A large number of industries deal with materials in powder form. The properties of these powders depend on their particle size, particle shape and size distributions, surface and porosity....
Strategic planning is a critical subject, central to the success of any scientific and economical enterprise. Not only is the scientific knowledge of many persons needed, but also an assessment of what may occur in the future – which approach...
This exceptional book reveals the results of twelve years of extensive thermoanalytical investigations into petroleum and its products with the aid of 236 tables, 284 diagrams and 159 references. Firstly, the methods employed in obtaining...
The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for...
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative...
Contributors to this volume explore the role of carbohydrates in communication between cells of multicellular organisms. Topics covered include the thermodynamics and spatial restrictions of oligosaccharide-protein interactions, the role of...
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and...
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was...